APOE Genetics - What Do These Lab Tests Mean?


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Happy functional medicine Friday, Dr. Julie McLaughlin here with McLaughlin care. So today we're gonna talk about another lab test panel, and this one is on genetics and is on one test called APOE. So, what does that mean? Right. Did you ever wonder, why do some diets work for some people and not for others?

Like some people they'll do keto and they do great. And other people they're like, oh, I did terrible. Some people do vegetarian and they're doing great. And some people don't. But why? And so you always hear, 'em like, well, you didn't do it right. Well, you didn't eat the right thing. Well, you ate this or, you know. There's another answer. It's in our jeans.

When we're born, we get certain cards, right. We get certain jeans and those cards are what you get. You have 'em for your whole life. And it's whether or not they express themselves or how they express themselves. And we can change that with our food, our nutrients that we take, and our lifestyle, because you don't wanna just let it go and throw everything up in the air and say, well, it's all my Gene's fault. No, you can absolutely control what's going on with those genes. And that process is called nutrigenomics, and this is how our genes interact with food.

When we look at the APOE, this is really what makes us unique. We get one from our mom and one from our dad, and this is a great gene to help us know how we're going to interact with certain nutrients and with the food we consume. APOE is really a critical protein in our cholesterol, and it it's important for cholesterol absorption from the intestines. So you can imagine if you absorb too much, you're gonna have high cholesterol. And if you don't absorb enough, you're gonna have low cholesterols. Do you see how that can affect.

So when we talk about this, sometimes the genetics can get a little tricky. I'm gonna give you a little refresher course. And the easiest thing is the male female, right. Female is X, X, and male is X. Y we get one allele from each parent. The Y determines the differentiation in the sex. So if you have a Y you're a male, and if you have two Xes, you're female, but in the male, they still have the X, but the Y makes the difference. So in the APOE it's really similar.

There's a three, three, right? The three is the thing that's pretty much common. And the three most common genotypes in this APOE are a three, a two, and a four. So there's some others that are pretty rare, but I'll tell you about those two in a second. So the three, three, you have a three from your mom, a three from your dad, right? Or a two, three. So if you get one from your mom, one from your dad, it makes you a two, right? So just like that y in the male thing that you're a two. If you have a three, four, then you're a four. Now the very rare ones, like less than 1% of a percentage, right? You could have a two, two, a four, four. Or a two, four.

So the two, four is very tricky. And we'll talk about that in a second. When we look at these, we wanna know what do tigers eat, right? Tigers, eat meat, their carnivores, but what about bears their omnivore. So they eat a little bit of plants. They eat a little bit of berries. They eat some fish. There might eat some animals. So they're omnivores. What about deer? They're pretty much veggie eaters. They're vegetarians. So guess what? We're the same way, but we can go to the grocery store and buy and eat whatever we want, but some of our genes are gonna be targeted to help us control those genes with our food.

So when we look at the APOE. Remember, there's gonna be the three main genotypes we're gonna talk about. So the 3 they're bears, they're like a omnivore they're middle of the road, and that's where we wanna be. 50% of your plate should be complex carbohydrates and 50% should be protein and fat. The deer. They're gonna be more veggie eaters.

Those are the people with the APOE 4, and they're gonna be more susceptible to heart disease and Alzheimer's, and you're like, what heck I don't, I don't want that. So if you have that